| N
|
| Drug |
CYP interaction |
Clinical consequences |
| naproxen
| CYP1A2 : metabolism
| ?
|
2C9 : METABOLISM (S-naproxen)
(? also 2C18 )
| ?
|
| nefazodone (antidepressant, 'new' class)
| 3A4 : INHIBITS
| raised triazolam, alprazolam, cyclosporine, carbamazepine,
haloperidol [Clin Pharmacokinet 1997 Oct;33(4):260-75],
tacrolimus and
cisapride levels , etc.
|
| nelfinavir
| 2C19 : substrate
| ?
|
| 3A4 : metabolism
| ?
|
| 3A4 : INHIBITS (Ki 4.8 µmol)
| ?
|
| CYP? : induces
| interaction with phenytoin! [Intern Med 1999 Mar;38(3):302-3]
|
| nevirapine
| 3A4 and 2B6 : METABOLISM, little or no inhibition of either
[Drug Metab Dispos 1999 Dec;27(12):1488-95]. In fact may
INDUCE 3A4.
|
Can decrease methadone levels [Pharmacotherapy 1999 Apr;19(4):471-2]
|
| nicardipine (see also calcium channel blockers)
| 3A4 : metabolism
| ?
|
| 3A4: INHIBITS (IC50 1 µM ?)
| ?
|
| 2D6 : inhibits (IC50 3 µM ?)
| interferes with propranolol removal [Fundam Clin Pharmacol 1994;8(4):373-8]
|
?
| 2C9 : inhibits (IC50 9 µM ?)
| ?
|
| nicotine : See smoking
|
| nifedipine
| 3A4 : substrate
(also 3A5, 3A7)
| complex interaction with e.g. grapefruit juice;
rifampin lowers bioavailability
|
| 1A2 : inhibits competitively
| ?
|
| nilutamide
| 2C19 : substrate
| ?
|
| nimodipine
| 3A4 : METABOLISM
| interaction (?) with 3A4 inhibitors eg. grapefruit juice,
carbamazepine, phenobarbitone or epanutin (levels plummet), valproate (increased levels).
|
| nisoldipine
| 3A4 : substrate
| interaction with inhibitors (grapefruit juice,.. ? cimetidine)
and inducers (rifampicin, phenytoin ..)
|
| 1A2 : inhibits
| ?
|
| nitrendipine
| 3A4 : substrate
| interactions with eg. grapefruit juice ; also impaired metabolism
with febrile illness! [Clin Pharmacokinet 1992 Sep;23(3):238-48]
|
| Neuroleptics
| CYP2D6 : low activity
| toxicity
|
| CYP2D6: hi activity
| ineffective
|
| Non-steroidal anti-inflammatory drugs (NSAIDs)
- SEE ALSO INDIVIDUAL AGENTS.
| CYP2C9 : metabolism
| avoid with methotrexate, warfarin, alcohol.
|
| norethindrone (=norethisterone)
| 2C19 : INDUCES
| ?
|
| 3A4 : metabolism
| potential for interaction with 3A4 inducers eg. troglitazone,
rifampin ( > rifabutin)
|
| norfloxacin
| 3A4 : INHIBITS
| ?
|
| norfluoxetine (a
fluoxtine metabolite)
| 3A4 : INHIBITS
| ?
|
| 2C19 : INHIBITS (Ki 7µmol)
| ?
|
| 2D6 : INHIBITS
| ? interaction potential
|
| nortriptyline
| 2D6 : metabolism
| ? interaction with e.g. inhibitors
|
| 2D6 : ? inhibits
| ?
|