CYP isoenzymes
CYP17 1 subfamily, 1 gene
(steroid biosynthesis)
Isoenzyme Substrates Inducer Inhibitor Alleles Effects (alleles, interactions)
CYP17 a portmanteau of two enzymes: 17 alpha hydroxylase and 17-20 lyase!; also metabolises aminopyrine   ketoconazole   A1 v A2 alleles implicated in a variety of hormone sensitive tumours {?}; A2/A2 genotype less likely to be on Hormone Replacement therapy!
blockade could turn off androgen synthesis!

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Last update 2000-1-22 Author