Cytochrome P450 : Alphabetical drug list
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1A2 2C9 2C19 2D6 2E1 3A4
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Drug CYP interaction Clinical consequences
Barbiturates 3A4 (3A5,3A7) : INDUCE Many potential 3A4-based interactions
barnidepine (calcium channel blocker) 3A4 : metabolism potential interaction with cyclosporine
2B6 : inhibits ?
2c9 : inhibits ?
2D6 : inhibits ?
2C19 : inhibits ?
3A4 : inhibits ?
Benzodiazepines {temazepam is exception to 3A4 metabolism} CYP3A4 : hi activity less effective
CYP3A4 : low activity delayed clearance
bepridil (Calcium 'antagonist' with anti-arrhythmic properties) 1A2 : mild inhibition
(? metabolism 3A4)
?? significant
Beta-blockers CYP2D6 : low activity prolonged and hi effect
bezafibrate (see fibrates) 3A4 : metabolism potential for 3A4 interactions
bisoprolol 2D6 (stereoselective, R>S) AND 3A4 (not) ?
bromocriptine 3A4 ? metabolism ?
brotizolam 3A4
[Xenobiotica 1997 Sep;27(9):913-22]
(bufuralol) 2D6 : metabolism (used as a reference for 2D6 metabolism, but 2C19 may catalyse the same reaction! [Drug Metab Dispos 1999 Sep;27(9):1024-8] ) ?
buspirone 3A4 : substrate grapefruit juice raises levels a lot!
[Clin Pharmacol Ther 1998 Dec;64(6):655-60] similarly with erythromycin, itraconazole [Clin Pharmacol Ther 1997 Sep;62(3):348-54]
busulfan 3A4 : METABOLISM interaction with eg intraconazole

Quick Links:
1A2 2C9 2C19 2D6 2E1 3A4

Page author: jo@anaesthetist.com Last update: 2000-6-22